Table 5. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) of clinical statuses associated with genotypic frequencies of histamine receptor H1 (HRH1) rs901865 in non-betel-quid chewers.
| Variable | Non-betel-quid chewers (N=311) | |||
| CC (N=254) | CT+TT (N=57) | AOR (95% CI)a | p value | |
| Clinical stage | ||||
| Stage I+II | 116 (45.7%) | 24 (42.1%) | 1.000 (reference) | 0.582 |
| Stage III+IV | 138 (54.3%) | 33 (57.9%) | 1.179 (0.656~2.121) | |
| Tumor size | ||||
| ≤T2 | 114 (44.9%) | 30 (52.6%) | 1.000 (reference) | 0.249 |
| >T2 | 140 (55.1%) | 27 (47.4%) | 0.709 (0.396~1.272) | |
| Lymph node metastasis | ||||
| No | 164 (64.6%) | 32 (56.1%) | 1.000 (reference) | 0.189 |
| Yes | 90 (35.4%) | 25 (43.9%) | 1.485 (0.823~2.679) | |
| Metastasis | ||||
| M0 | 252 (99.2%) | 56 (98.3%) | 1.000 (reference) | 0.412 |
| M1 | 2 (0.8%) | 1 (1.7%) | 2.798 (0.240~32.609) | |
| Cell differentiated grade | ||||
| Well | 23 (9.1%) | 9 (15.8%) | 1.000 (reference) | 0.151 |
| Moderately or poorly | 231 (90.9%) | 48 (84.2%) | 0.542 (0.235~1.251) | |
Cell differentiate grade: grade I, well differentiated; grade II, moderately differentiated; grade III, poorly differentiated.
aThe AORs with their 95% CIs were estimated by multiple logistic regression models after controlling for age, cigarette smoking, and alcohol consumption.