Table 1. Overall, we noted that the dose of 50 mg/kg of CQ did not cause significant pathological changes in the liver and heart.

Liver

50 mg/kg

100 mg/kg

200 mg/kg

Pathological grading

GVD

PII

PF

HN

GVD

PII

PF

HN

GVD

PII

PF

HN

Mild (+)

1/10

0/10

1/10

2/10

3/10

2/10

0/10

2/10

3/10

3/10

2/7

5/10

Moderate (++)

3/10

1/10

0/10

1/10

4/10

0/10

0/10

1/10

2/10

1/10

0/7

5/10

Severe (+++)

1/10

0/10

0/10

1/10

3/10

0/10

0/10

0/10

2/10

0/10

0/7

0/10

Abbreviations: GVD: Granulovacuolar degeneration; PII: Portal inflammatory infiltrate; PF: Portal fibrosis HN: hepatocyte necrosis.