Table 2.
Individual Subset Associations With Lead Pleiotropic SNP rs7084454
| Cancer | EAFa | OR (95% CI) | P-value |
|---|---|---|---|
| Meningioma | 0.34 | 1.36 (1.17–1.57) | 3.3 × 10–5 |
| Females | 1.42 (1.20–1.69) | 3.9 × 10–5 | |
| Males | 1.19 (0.91–1.57) | 0.20 | |
| Breast (all) | 0.34 | 1.03 (1.01–1.06) | 0.015 |
| ER+ | 1.05 (1.02–1.08) | 2.4 × 10–3 | |
| ER– | 0.91 (0.86–0.96) | 8.9 × 10–4 | |
| Ovarian | 0.33 | 1.09 (1.06–1.12) | 2.4 × 10–10 |
| Serous high grade | 1.10 (1.07–1.14) | 2.8 × 10–9 | |
| Serous low grade | 1.10 (1.00–1.22) | 0.049 | |
| Mucinous | 0.99 (0.91–1.08) | 0.86 | |
| Clear cell | 1.12 (1.03–1.21) | 9.0 × 10–3 | |
| Endometrioid | 1.06 (1.00–1.13) | 0.048 |
aEAF: Effect allele frequency in controls, where “A” is the effect allele and “G” is the alternate allele.