Table 3.
Association of Lead Pleiotropic SNP rs7084454 With Additional Traits in PheWAS Analysis of UK Biobank Data (N = 452 264)
| Trait | Betaa | P-valueb |
|---|---|---|
| Leg fat percentagec | 0.11 | 1.7 × 10–30 |
| Leg fat massc | 0.029 | 2.6 × 10–25 |
| Body fat percentage | 0.12 | 7.4 × 10–25 |
| Waist circumference | 0.23 | 9.2 × 10–25 |
| Whole body fat mass | 0.17 | 2.5 × 10–23 |
| Trunk fat mass | 0.090 | 2.5 × 10–22 |
| Body mass index (BMI) | 0.082 | 7.5 × 10–22 |
| Trunk fat percentage | 0.13 | 8.9 × 10–22 |
| Oily fish intake | –0.018 | 3.5 × 10–21 |
| Hip circumference | 0.16 | 2.2 × 10–20 |
| Fresh fruit intake | –0.028 | 5.9 × 10–20 |
| Arm fat percentagec | 0.12 | 3.3 × 10–19 |
| Arm fat massc | 0.0098 | 2.6 × 10–18 |
| Weight | 0.21 | 1.0 × 10–17 |
| Time spent watching television (TV) | 0.024 | 2.2 × 10–13 |
| Waist circumference/ Hip circumference | 0.00092 | 5.8 × 10–13 |
| Essential hypertension | 0.0052 | 2.3 × 10–11 |
| Hypertensive diseases | 0.0052 | 2.5 × 10–11 |
| Number of operations, self-reported | 0.021 | 3.5 × 10–11 |
| Monocyte count | 0.0019 | 1.2 × 10–10 |
| Dried fruit intake | –0.019 | 3.2 × 10–10 |
| Usual walking pace | –0.0078 | 4.6 × 10–10 |
| Salad/ raw vegetable intake | –0.025 | 5.7 × 10–10 |
| Arm fat-free massc | 0.0049 | 3.0 × 10–9 |
| Arm predicted massc | 0.0045 | 4.9 × 10–9 |
| Number of treatments/medications taken | 0.031 | 6.7 × 10–9 |
| Basal metabolic rate | 8.1 | 1.8 × 10–8 |
| Leg fat-free mass (left) | 0.012 | 2.3 × 10–8 |
| Impedance of armc | –0.37 | 3.9 × 10–8 |
| Leg predicted mass (left) | 0.011 | 4.0 × 10–8 |
aBeta values correspond to the direction of effect associated with each additional copy of the rs7084454 “A” allele, which is the allele associated with increased risk of meningioma, ovarian cancer and ER+ breast cancer, and decreased risk of ER– breast cancer, in our analyses.
bSeven hundred and seventy-eight total traits were queried. Those displayed in Table 3 had P-values < 5.0 × 10–8, a canonical cutoff for genome-wide statistical significance.
cA number of traits in UK Biobank are stratified by laterality (eg, “leg fat percentage, left” and “leg fat percentage, right”). When each of a pair of lateral traits reached genome-wide significance, only one member of the pair is listed in Table 3.