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. Author manuscript; available in PMC: 2023 Apr 5.
Published in final edited form as: J Am Coll Cardiol. 2022 Apr 5;79(13):1254–1265. doi: 10.1016/j.jacc.2022.01.038

Figure 1. Study outline.

Figure 1.

Each 21-day study period consisted of 4 days/3 nights of acclimation (Days 1-4), then a 14-day/14-night experimental phase (Days 5-18), followed by a 3-day/3-night recovery (Days 19-21). Participants completed both sleep restriction and control sleep conditions in randomized order, after a >3-month wash-out. Gray bar indicates 9 hours of time in bed (from 22:00 to 7:00), while red bar indicates 4 hours of time in bed (from 00:30 to 4:30).