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. 2021 Nov 5;74(11):1899–1905. doi: 10.1093/cid/ciab711

Figure 3.

Figure 3.

Neutralization of variant pseudoviruses by human antisera across different doses and fold reduction in the neutralization of D614G, Alpha, and Beta variants relative to wild-type (wt). A, 50% inhibition dilution (ID50) and 90% inhibition dilution (ID90) neutralizing titers of each dose group were plotted for the WT and variants with data from Figure 2. Bars and error bars represent geometric mean titers (GMTs) and 95% confidence intervals, respectively. B, Fold reduction in neutralization vs the WT was calculated by dividing the average ID50 and ID90 titers of WT by ID50 and ID90 titers of each variant. Results are plotted as bars and error bars indicating mean and standard deviation, respectively. Kruskal-Wallis with Dunnett multiple comparisons test was used to compare neutralizing titers and ratios of variants relative to WT at high-dose (HD), medium-dose (MD), and low-dose (LD) levels. ****P < .0001.