Figure 3.

Prediction of Staphylococcus aureus metastatic infection using duration of microbial cell-free DNA (mcfDNA) detection/positivity. Logistic regression predictions of metastatic infection conditioned on days of detectable plasma mcfDNA and type of infection (S. aureus bacteremia or gram-negative bacteremia). Briefly, 125 patients were used to construct an additive 2-parameter model (pseudo r-squared 0.315, Brier score = 0.16, Harrell’s concordance index = 0.791). The predicted log of odds from the fitted model (y-axis) using days of detectable mcfDNA (x-axis; odds ratio [OR], 2.89; 95% confidence interval [CI], 1.53–5.46 for each additional day) and class of infection (OR, 3.61; 95% CI, 1.40–9.26 for S. aureus infection) are shown. Abbreviations: Gram Neg, gram-negative; Staph aureus, Staphylococcus aureus.