Table 1.
HOPE Donor Characteristics in Human Immunodeficiency Virus–Positive and False-Positive Donors
| Donors, No. (%)a | P Valueb | |||
|---|---|---|---|---|
| Donor Characteristic | Total (n = 92) | HIV Positive (n = 58) | HIV FP (n = 34) | |
| Age, median (IQR), y | 33.0 (28.0–44.0) | 36.0 (29.0–46.0) | 31.0 (23.0–41.0) | .01 |
| Male sex | 67 (72) | 44 (76) | 22 (65) | .25 |
| Race | ||||
| White | 37 (41) | 22 (38) | 15 (44) | .21 |
| Black | 37 (40) | 27 (47) | 10 (29) | |
| Other | 18 (19) | 9 (16) | 9 (26) | |
| BMI, median (IQR)c kg/m2 | 26.1 (22.7–30.5) | 25.2 (22.7–29.0) | 28.4 (22.1–34.8) | .11 |
| Diabetes | 9 (10) | 5 (9) | 4 (12) | .64 |
| Hypertension | 25 (27) | 16 (28) | 9 (26) | .87 |
| CAD | 3 (3) | 1 (2) | 2 (6) | .29 |
| Cause of death | ||||
| Anoxia | 38 (41) | 27 (47) | 11 (32) | .53 |
| Cerebrovascular | 24 (26) | 14 (24) | 9 (26) | |
| Head trauma | 28 (30) | 15 (26) | 13 (38) | |
| Other | 3 (3) | 2 (3) | 1 (3) | |
| Mechanism of death | ||||
| Drug intoxication | 19 (21) | 15 (26) | 4 (12) | .11 |
| Cardiovascular | 12 (13) | 9 (16) | 3 (9) | .36 |
| Suicide | 9 (10) | 7 (12) | 2 (6) | .33 |
| Results of serologic screening | ||||
| HCV Ab+ | 4 (4) | 1 (2) | 3 (9) | .11 |
| HCV NAT+ d | 3 (3) | 1 (2) | 2 (6) | .56 |
| HBV Ab+ | 9 (10) | 9 (16) | 0 (0) | .02 |
| CMV IgG+ | 72 (79) | 53 (91) | 19 (58) | <.001 |
| Toxoplasma IgG+ | 5 (6) | 3 (6) | 2 (7) | .84 |
| Syphilis (RPR) | 9 (10) | 9 (16) | 0 (0) | .02 |
| Organ donated | ||||
| Kidney (≥1) | 77 (84) | 46 (79) | 31 (91) | .14 |
| Liver | 46 (52) | 34 (59) | 12 (35) | .03 |
| Kidney and liver | 31 (34) | 22 (38) | 9 (26) | .17 |
| KDPI, median (IQR) % | 40 (28– 62) | 41 (30– 63) | 36 (21– 60) | .20 |
| DCD | 11 (12) | 4 (7) | 7 (21) | .05 |
| Steroid given | 60 (66) | 42 (72) | 18 (55) | .08 |
| PHS increased risk | 62 (67) | 47 (81) | 15 (44) | <.001 |
Abbreviations: Ab, antibody; BMI, body mass index; CAD, coronary artery disease; CMV, cytomegalovirus; DCD, donation after circulatory death; FP, false-positive; HBV, hepatitis B virus (hepatitis B core Ab); HCV, hepatitis C virus; HIV, human immunodeficiency virus; HOPE, HIV Organ Policy Equity; IgG, immunoglobulin G; IQR, interquartile range; KDPI, kidney donor profile index; NAT, nucleic acid testing; PHS, Public Health Service; RPR, rapid plasma reagin.
aData represent no. (%) of donors unless otherwise specified.
bComparisons are unadjusted.
cBMI calculated as weight in kilograms divided by height in meters squared.
dTwo other FP donors had FP results of HCV screens with multiplex HIV/HCV/HBV NAT, with negative confirmatory quantitative polymerase chain reaction results (omitted from table).