Table 2.
Donor Human Immunodeficiency Virus History, Screening, and Biology
| Donors, No. (%)a | ||
|---|---|---|
| HIV Factor | HIV Positive (n = 58) | HIV FP (n = 34) |
| Reactive HIV screening assayb | ||
| Anti-HIV I/II Ab | 58 (100) | 27 (79) |
| HIV qualitative NAT | 40 (69) | 5 (15) |
| Ab/Ag+ | … | 1 (3) |
| Confirmatory rule-out assayc | ||
| Western blot | … | 25 (74) |
| Ag/Ab (4th generation) | … | 7 (21) |
| Quantitative PCR | … | 4 (12) |
| Time of HIV diagnosis | ||
| Prior knowledge | 41 (71) | … |
| At admission | 14 (24) | … |
| Unknown | 3 (5) | … |
| HIV risk categoryd | ||
| MSM | 25 (43) | … |
| IDU | 13 (22) | … |
| Heterosexual sex | 16 (28) | … |
| Perinatal | 1 (2) | … |
| Other or unknown | 16 (28) | … |
| Reported ART use | ||
| Yes | 37 (64) | … |
| No | 15 (26) | … |
| Unknown | 6 (10) | … |
| CD4 T-cell findings at donatione | ||
| Count, median (IQR), cells/µL | 194 (77–331) | … |
| Proportion, median (IQR), % | 27.0 (16.8–36.1) | … |
| Count <200/µL | 27 (51) | … |
| Proportion <14% | 11 (22) | … |
| HIV VL at donationf | ||
| Median (IQR), copies/mL | 882 (<40 to 20 417) | … |
| Log VL, median (IQR) | 2.9 (1.0–4.3) | … |
| VL <400 copies/mL | 27 (47) | … |
| CC tropismg | ||
| R5 | 19 (68) | … |
| Dual R5-X4 | 9 (32) | … |
| X4 | 0 (0) | … |
Abbreviations: Ab, antibody; Ag, antigen; ART, antiretroviral therapy; CC, chemokine coreceptor; FP, false-positive; HIV, human immunodeficiency virus; HOPE, HIV Organ Policy Equity; IQR, interquartile range; IDU, injection drug use; MSM, men who have sex with men; NAT, nucleic acid testing; PCR, polymerase chain reaction; VL, viral load.
aData represent no. (%) of donors unless otherwise specified.
bNo FP donor had >1 positive screening assay result, and 1 screened positive by medical history only. All NAT-positive FP donors were tested with a multiplex qualitative assay (HIV/hepatitis B virus/hepatitis C virus). One FP donor had reactive HIV Ag (Ab negative).
cSee Supplementary Table 1 for additional information; multiple rule-out assays were used for individual donors.
dRisk categories are not mutually exclusive. “Heterosexual sex” includes sex work and intercourse with sex workers.
eDonation CD4 T-cell counts were available for 53 donors, and CD4 T-cell percentages for 51.
fVL <40 copies/mL was set at 10 copies/mL (1 log) for analysis.
gHIV tropism results in 38 donors with successful assays.