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. 2022 Jun 3;2022:9144644. doi: 10.1155/2022/9144644

Figure 2.

Figure 2

Metformin or DQ alone or in combination with each other alleviated the senescent stress induced by cisplatin in vivo. (a) Flowchart of drug administration animal experiment. (b, c) Light microscopic images of SA-β-gal staining and P16link4a, P21WAF1/Cip1, and IL-6 IHC staining after different medications. Scar bars are marked on respective images (n =3). (d–g) Quantitative analysis of SA-β-gal–positive area and P16link4a-, P21WAF1/Cip1-, and IL-6-postive IOD (n =3). Results are presented using mean ± standard deviation values. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.