Table 1.
The correlations between MTHFD family genes and clinical characteristics by logistic regression analysis.
| Characteristics | MTHFD1 | MTHFD1L | MTHFD2 | MTHFD2L | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total (N) | Odds Ratio (OR) | P value | Total (N) | Odds Ratio (OR) | P value | Total (N) | Odds Ratio (OR) | P value | Total (N) | Odds Ratio (OR) | P value | |
| T stage (T3 and T4 versus T1 and T2) | 319 | 1.309 (0.834–2.061) | 0.243 | 319 | 1.282 (0.817–2.019) | 0.281 | 319 | 1.733 (1.101–2.743) | 0.018 | 319 | 1.474 (0.938–2.326) | 0.093 |
| N stage (N1, N2, and N3 versus N0) | 315 | 1.456 (0.934–2.276) | 0.098 | 315 | 1.123 (0.721–1.750) | 0.609 | 315 | 1.378 (0.884–2.152) | 0.157 | 315 | 1.119 (0.718–1.744) | 0.619 |
| M stage (M1 versus M0) | 312 | 0.975 (0.038–24.791) | 0.985 | 312 | 82002730.329 (0.000-NA) | 0.996 | 312 | 1.026 (0.040–26.104) | 0.985 | 312 | 0.000 (NA-2380550791035) | 0.996 |
| Clinical stage (Stage III and Stage IV versus Stage II and Stage I) | 319 | 1.491 (0.914–2.446) | 0.111 | 319 | 1.215 (0.746–1.985) | 0.435 | 319 | 1.741 (1.064–2.872) | 0.028 | 319 | 1.270 (0.780–2.078) | 0.337 |
| Radiation therapy (Yes versus No) | 295 | 0.678 (0.423–1.084) | 0.105 | 295 | 1.185 (0.742–1.894) | 0.477 | 295 | 1.229 (0.770–1.967) | 0.388 | 295 | 1.135 (0.711–1.816) | 0.595 |
| Primary therapy outcome (PD and SD versus CR and PR) | 278 | 0.911 (0.460–1.798) | 0.787 | 278 | 0.911 (0.460–1.798) | 0.787 | 278 | 1.784 (0.900–3.637) | 0.102 | 278 | 0.754 (0.377–1.485) | 0.416 |
| Gender (Male versus Female) | 329 | 1.009 (0.632–1.611) | 0.971 | 329 | 0.900 (0.563–1.437) | 0.660 | 329 | 1.505 (0.942–2.418) | 0.089 | 329 | 1.690 (1.056–2.723) | 0.030 |
| Race (Asian and Black or African American versus White) | 318 | 1.363 (0.641–2.962) | 0.423 | 318 | 1.826 (0.852–4.097) | 0.129 | 318 | 1.586 (0.744–3.494) | 0.238 | 318 | 1.459 (0.684–3.214) | 0.334 |
| Age (>60 versus ≤60) | 328 | 0.951 (0.616–1.467) | 0.820 | 328 | 0.999 (0.647–1.541) | 0.995 | 328 | 1.340 (0.868–2.073) | 0.187 | 328 | 0.611 (0.394–0.944) | 0.027 |
| Histologic grade (G3 and G4 versus G1 and G2) | 321 | 1.126 (0.661–1.925) | 0.662 | 321 | 1.848 (1.077–3.223) | 0.027 | 321 | 1.566 (0.917–2.701) | 0.102 | 321 | 1.046 (0.613–1.785) | 0.869 |
| Smoker (Yes versus No) | 323 | 0.977 (0.597–1.599) | 0.927 | 323 | 1.041 (0.636–1.704) | 0.874 | 323 | 1.147 (0.701–1.879) | 0.586 | 323 | 1.041 (0.636–1.704) | 0.874 |
| Alcohol history (Yes versus No) | 321 | 1.079 (0.676–1.722) | 0.751 | 321 | 1.119 (0.702–1.787) | 0.636 | 321 | 1.352 (0.848–2.164) | 0.206 | 321 | 1.490 (0.933–2.392) | 0.096 |
| Lymphovascular invasion (Yes versus No) | 239 | 1.032 (0.597–1.786) | 0.911 | 239 | 0.778 (0.449–1.344) | 0.368 | 239 | 1.273 (0.736–2.213) | 0.389 | 239 | 0.923 (0.533–1.595) | 0.774 |
| Lymph node neck dissection (No versus Yes) | 327 | 1.143 (0.608–2.161) | 0.678 | 327 | 1.143 (0.608–2.161) | 0.678 | 327 | 1.045 (0.556–1.971) | 0.890 | 327 | 1.588 (0.842–3.055) | 0.157 |
The bold values means p value < 0.05, and the other unbold values mean p value > 0.05.