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. 2022 May 2;45(3):415–428. doi: 10.1007/s13402-022-00674-9

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Fig. 6 — Melatonin induces a decrease in p-ERK expression in osteosarcoma cells, which is not abolished by calcium chloride. (a) Evaluation of the effect of melatonin p-AKT and p-ERK expression. Melatonin treatment induces a decrease in p-ERK expression in MG63 cells. (b) Supplementation of osteosarcoma cells with calcium chloride does not significantly abolish the decrease in p-ERK expression caused by melatonin after 24 h of treatment. Optical density reading values versus loading control GAPDH are presented. Dashed line indicates control group levels in all graphs. * p ≤ 0.05 vs control group (vehicle-treated cells). # p ≤ 0.05 vs melatonin group