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. 2022 May 2;45(3):415–428. doi: 10.1007/s13402-022-00674-9

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Fig. 7 — Antioxidants enhance melatonin-induced inhibition of cell viability, but do not affect intracellular calcium levels or mitochondrial membrane potential. (a) Trolox and ascorbate potentiate melatonin effects on the number of viable cells after 48 h of treatment. (b) Treatment with trolox or ascorbate for 24 h does not modify cytosolic calcium levels or (c) mitochondrial membrane potential. (d) Combined treatment for 24 h of melatonin with Trolox does not modify the effect of the indolamine on cytosolic calcium levels or (e) mitochondrial membrane potential. Dashed line indicates control group levels in graphs b-e. * p ≤ 0.05 vs control group (vehicle-treated cells). # p ≤ 0.05 vs melatonin group