Table 1.
Baseline characteristics by BMI at baseline--BENEFIT
| Body mass index at baseline, kg per m2 | ||||
|---|---|---|---|---|
| <18.5 (N = 18) | 18.5–<25 (N = 271) | 25–<30 (N = 119) | ≥30 (N = 57) | |
| BMI, kg per m2 | 18.0 (17.0–18.0) | 22.0 (21.0–23.0) | 27.0(25.0–28.0) | 32.5 (31.0–35.0) |
| Age at baseline, years* | 29.6 (5.9) | 30.1 (7.4) | 31.6 (7.6) | 32.7 (7.4) |
| Female, % | 91.3 | 71.9 | 62.8 | 69.5 |
| Active smokera, % | 29.6 | 32.1 | 33.7 | 35.8 |
| Country or region | 82.3 | 69.6 | 66.2 | 55.7 |
| Central Europeb, % | ||||
| Canada, % | 14.6 | 4.1 | 7.1 | 7.5 |
| Scandinavia, % | 0.0 | 8.9 | 14.8 | 16.0 |
| Southern Europe, % | 3.1 | 17.4 | 11.9 | 20.8 |
| Time to CDMS, days | 415 (141–1,497) | 1,176 (351–1,804) | 1,064 (342–1,805) | 672 (136–1,806) |
| Time to MDMSd, days | 191 (96.0–372.0) | 194 (100–700) | 214.0 (96.0–929.0) | 100 (86–558) |
| INFß-1b treatment group, % | 62.1 | 62.6 | 68.1 | 51.0 |
| Multifocal onset, % | 52.1 | 47.4 | 51.6 | ]29.0 |
| T2 lesion number at screening | 33 (9.0–52.0) | 19.0 (7.0–40.0) | 17.0(8.0–33.0) | 13.0 (5.0–35.0) |
| T2 lesion volume at screening, mm3 | 2,044 (1,107–8664) | 1,871 (621–4,790) | 1,947 (718–4,343) | 1,717 (389–2,987) |
| Brain volume at screening, cm3 | 1,073 (1,056–1,097) | 1,056 (1,022–1,084) | 1,056 (1,019–1,082) | 1,048 (1,029–1070) |
| EDSS at baseline | 1.5(1.0–2.0) | 1.5(1.0–2.0) | 1.5 (1.0–2.0) | 1.5(0.0–2.0) |
| 25(OH)D at baseline, nmol/L | 45.8 (38.5–61.3) | 47.0 (37.6–59.0) | 48.0 (37.7– 58.5) | 43.9 (34–51.6) |
| Steroid use at baseline, % | 72.9 | 74.6 | 62.3 | 75.6 |
Values are medians (interquartile ranges) or percentages and are standardized to the age distribution of the study population.
*
Value is not age adjusted
a
Active smoker defined as having all cotinine measures—baseline, months 6, 12, and 24— >25 ng/mL
b
Central Europe: Belgium, Netherlands, Germany, Austria, Switzerland, Denmark, France, Great Britain, Hungary, Czech Republic, Poland, Slovenia; Southern Europe: Spain, Portugal, Italy, Israel; Scandinavia: Finland, Norway, Sweden
d
2001 McDonald MS