Table 4:

Percentage annual change in cerebral T2 lesion volume and brain volume by BMI

Body mass index categories
	<18.5	18.5–<25	25–<30	≥30	P trend
T2 lesion volume* a (% change, 95% CI)
All	−0.86 (−38.7, 37)		9.8 (−6.8, 26.4)	5.0 (−17.5, 27.6)	0.39
Non-smokers	−10.1 (−55.8, 35.5)	Ref	−3.55 (−23.1, 16)	−0.23 (−25.7, 25.2)	0.97
Active smokers	−2.7 (−91.3, 85.8)		29.9 (−10.4, 70.1)	13.3 (−43.0, 69.6)	0.34
Brain volume, cm3 a (% change, 95% CI)
All	0.04 (−0.49, 0.56)	Ref	−0.09 (−0.34, 0.16)	−0.11 (−0.45, 0.22)	0.39
Non-smokers	0.20 (−0.54, 0.94)		0.04 (−0.28, 0.36)	−0.02 (−0.44, 0.40)	0.90
Active smokers	0.01 (−0.95, 0.96)		−0.27 (−0.78, 0.23)	−0.78 (−1.47, −0.09)	0.03

Adjusted for age, sex, smoking status, region of residence, treatment allocation, baseline serum 25(OH) vitamin D with seasonal correction, no. T2 lesions at baseline, steroid treatment at baseline, EDSS at baseline (volume analyses only) and CIS onset type.

^aFrom 12 to 60 months

^bFrom 6 to 60 months

^*Two extreme outliers with very high change in T2 lesion volume were excluded.