Table 4.

Univariable and multivariable analysis for the prediction of myocardial infarction

	Univariable		Multivariable#
	HR (95% CI)	P value	HR (95% CI)	P value
Total plaque burden*	1.44 (1.15–1.18)	<0.001	1.33 (0.97–1.82)	0.072
NCP burden*	1.41 (1.14–1.75)	<0.001	1.30 (0.96–1.75)	0.088
LAP burden*	1.87 (1.36–2.57)	<0.001	1.80 (1.16–2.80)	0.009
CP burden*	1.70 (1.26–2.12)	<0.001	1.55 (0.92–2.63)	0.102
PCAT-RCA§	1.55 (1.08–2.22)	0.017	1.54 (1.02–2.12)	0.038
Cardiovascular risk score	1.03 (1.00–1.05)	0.046	1.01 (0.98 – 1.05)	0.374
CACS*	1.2 (1.10–1.3)	<0.001	0.93 (0.74 – 1.16)	0.493
Obstructive disease	3.02 (1.60–5.8)	<0.001	1.09 (0.47 – 2.52)	0.835
High-risk plaque features (≥1)	3.12 (1.60–6.06)	<0.001	0.95 (0.41–2.19)	0.901
PCAT-RCA volume§	1.082 (0.77–1.52)	0.654	1.00 (0.99–1.00)	0.615

^#Multivariable analysis includes the individual quantitative plaque measure, Agatston calcium score, obstructive disease and cardiovascular risk score. Full model results are presented in Table i in the Supplemental Appendix. Multivariable analysis of cardiovascular risk score, CACS, obstructive disease, presence of high-risk plaque features and adipose tissue volume (PCAT-RCA volume) includes all different types of plaque burden.

^*Per doubling.

^§Per 1 standard deviation increment in PCAT attenuation.

HR, hazard ratio; CI, confidence interval; NCP, non-calcified plaque; LAP, low-attenuation plaque; CP, calcified plaque; PCAT-RCA, pericoronary adipose tissue attenuation of the right coronary artery; CACS, coronary artery calcium score.