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. Author manuscript; available in PMC: 2023 Jun 8.
Published in final edited form as: Cell Host Microbe. 2022 Apr 27;30(6):848–862.e7. doi: 10.1016/j.chom.2022.03.036

Figure 4.

Figure 4.

Systemic effects associated with strong AX cholesterol responders relative to non-responders. NR = non-responders; R = responders. A) From stool samples relative abundances of the genus Helicobacter and the metagenomic gene feruloyl esterase in the two categories. Y-axis is log2 fold change relative to baseline. P-values determined by Wilcoxon rank sum, FDR corrected. B) In clinical serum samples, comparing total proteins and triglycerides between categories. P-values determined by Wilcoxon rank sum, FDR corrected. C) Volcano plot showing proteins significantly increased in the responder group. X-axis is the value of the protein at 30g AX relative to baseline, and y-axis is log2 fold change. Two sample t-test, permutation based FDR 0.05 (number of randomizations is 250) and S0 correction 0.1 were applied using Perseus. D) The ratio of dietary protein to fiber in responders vs non-responders. P-value determined by Wilcoxon rank sum, FDR corrected. See Tables S4B, S4C, S4d, S5A and S5B.