Antibodies |
Anti-mouse CD45 Pacific Blue |
BioLegend |
Cat#103125 |
Anti-mouse CD3 FITC |
BioLegend |
Cat#100306 |
Anti-mouse CD4 APC Cy7 |
BioLegend |
Cat#100414 |
Anti-mouse CD19 PerCP Cy5.5 |
eBioscience |
Cat#45019842 |
Anti-mouse Tbet APC |
BioLegend |
Cat#644814 |
Anti-mouse GATA3 PE |
eBioscience |
Cat#12698180 |
Anti-mouse FoxP3 PE Cy7 |
BioLegend |
Cat#137235 |
Anti-mouse IFN AF700 |
BioLegend |
Cat#505824 |
Bacterial and virus strains |
E. coli: BW25113: F-, Δ(araD-araB)567, ΔlacZ4787(::rrnB-3), λ-, rph-1, Δ(rhaD-rhaB)568, hsdR514
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: GC1547: BW25113 transformed with pET28 |
this study |
N/A |
E. coli: GC1549: BW25113 ΔfabF::kan
|
this study |
N/A |
E. coli: GC1558: ΔeutN::kan, pGC735 |
this study |
N/A |
E. coli: GC1559: ΔfabH::kan, pGC738 |
this study |
N/A |
E. coli: GC1643: ΔeutC::kan
|
this study |
N/A |
E. coli: GC1644: BW25113 ΔeutC
|
this study |
N/A |
E. coli: GC1645: BW25113 ΔeutN::kan
|
this study |
N/A |
E. coli: GC1646: BW25113 ΔeutN
|
this study |
N/A |
E. coli: GC1647: BW25113 ΔeutC ΔeutN::kan
|
this study |
N/A |
E. coli: GC1648: BW25113 ΔeutC::kan ΔeutN
|
this study |
N/A |
E. coli: GC1649: BW25113 ΔeutD
|
this study |
N/A |
E. coli: GC1650: BW25113 ΔeutD pPlac-eutD |
this study |
N/A |
E. coli: JW1077: BW25113 ΔfabH::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW2442: BW25113 ΔeutD::kan |
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW2440: BW25113 ΔeutN::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW2294: BW25113 Δpta::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW3595: BW25113 ΔrfaF::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW3818: BW25113 ΔrfaH::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW4334: BW25113 ΔholD::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW1859: BW25113 ΔcmoA::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW3397: BW25113 ΔyhgN::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW3929: BW25113 ΔargE::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
E. coli: JW3932: BW25113 ΔargH::kan
|
National BioResource Project at the National Institute of Genetics, Japan (Baba et al., 2006) |
N/A |
Chemicals, peptides, and recombinant proteins |
|
|
L-arginine monohydrochloride |
Sigma-Aldrich |
Cat#A5131 |
L-ornithine monohydrochloride |
Sigma-Aldrich |
Cat#O2375 |
Acetaldehyde |
Chem Service |
Cat#S-11005A4 |
Ethanolamine |
Sigma-Aldrich |
Cat#E0135 |
N-acetyl cysteine |
Sigma-Aldrich |
Cat#A9165 |
Roche Diagnostics LIGHTCYCLER 480 SYBR GREEN |
Roche |
Cat#04887352001 |
Critical commercial assays |
|
|
RNeasy Plus Mini Kit |
QIAGEN |
Cat#74136 |
QIAprep Spin Miniprep Kit |
QIAEX II Gell Extraction Kit |
QIAGEN |
Cat#20021 |
High-Capacity cDNA Reverse Transcription Kit |
Thermo Fisher |
Cat#4368814 |
Deposited data |
|
|
RNA sequencing reads |
NCBI Sequence Read Archive |
PRJNA803354 |
Experimental models: Organisms/strains |
|
|
Mouse: C57BL/6J |
The Jackson Laboratory |
JAX: 000664 |
Mouse: NOD.CgPrkdcscid/J |
The Jackson Laboratory |
JAX: 001303 |
C. elegans: GC833: glp-1(ar202) III |
E. Jane Hubbard, (Pepper et al., 2003) |
N/A |
C. elegans: GC1250: daf-16(m26) I; daf-2(e1370) glp-1(e2141) III |
E. Jane Hubbard, (Michaelson et al., 2010) |
N/A |
C. elegans: GC1474: glp-1(e2141) III; hjSi20 [Pmyo-2P::mCherry::unc-54 3’UTR] IV; zuIs70 [pJN152: end-1P::gfp::caax; unc-119(+)] V |
this paper |
N/A |
C. elegans: GC1545: daf-5(e1386) II; glp-1(e2141) III |
this paper |
N/A |
|
|
|
Oligonucleotides |
|
|
See table S4. |
|
|
Recombinant DNA: List of plasmids used in this study |
pGC735, eutN cloned into pBR322 by Gibson assembly |
this paper |
|
pGC737, pET28 |
this paper |
|
pGC738, fabH cloned into pBR322 by Gibson assembly |
this paper |
|
pPlac-eutD, eutD under the control of a lacUV5 promoter |
this paper |
|
pBR322 |
Sigma-Aldrich |
Cat#OGS589 |
|
Sigma-Aldrich |
Cat#69864-3 |
Software and algorithms |
Flowjo 10.0.8 |
Flowjo, LLC |
https://flowjo.com/
|
Illustrator CC |
Adobe |
https://www.adobe.com/products/illustrator.html
|
ImageJ |
|
https://imagej.nih.gov
|
ActivityBase |
IDBS |
https://www.idbs.com
|
Software: R v3.4.1 |
|
https://www.r-statistics.com/
|