Table 1.

Docking scores (Kcal·mol⁻¹) of the chalcones against the ZIKV NS2B-NS3 protease and the NS5 RdRp. Values were obtained using Autodock Vina [29] software.

	docking score (Kcal·mol−1)
compound	NS2B-NS3 Protease		NS5 RdRp†
	Allosteric pocket*	Catalytic site§	N-pocket
4-HD	−8.0	−6.5	−3.1
XA	−7.6	−7.0	−3.8
XA-E	−8.0	−7.2	−4.4

crystallographic structures: PDB ID

^*5GXJ;

^§5YOD;

^†5TFR