Table 4.
Meta-analyses of biomarkers by individual antipsychotics.
| Antipsychotic | Biomarkers | Number of studies | SMD (se) | P-value | I2 |
|---|---|---|---|---|---|
| Aripiprazole | Prolactin | 3 | −0.978 (0.895) | 0.275 | 91.9* |
| Haloperidol | Cortisol | 3 | −0.236 (0.215) | 0.273 | 51.8 |
| Haloperidol | Prolactin | 6 | 1.358 (0.156) | <0.001 | <1 |
| Olanzapine | Adiponectin | 4 | 0.323 (0.264) | 0.222 | 63.8* |
| Olanzapine | Cortisol | 5 | −0.794 (0.256) | 0.002 | 62.6* |
| Olanzapine | C-peptide | 4 | 0.604 (0.227) | 0.008 | 30.7 |
| Olanzapine | FFA | 4 | −0.492 (0.134) | <0.001 | <1 |
| Olanzapine | Ghrelin | 4 | −0.252 (0.170) | 0.137 | <1 |
| Olanzapine | Glucagon | 3 | 0.424 (0.285) | 0.136 | 22.3 |
| Olanzapine | IL-6 | 3 | −0.023 (0.238) | 0.924 | 46.3 |
| Olanzapine | Leptin | 7 | 0.317 (0.122) | 0.009 | <1 |
| Olanzapine | Prolactin | 5 | 1.443 (0.230) | <0.001 | 33.3 |
| Olanzapine | TNFα | 3 | 0.313 (0.232) | 0.178 | 42.5 |
Random effects analyses include standardized mean differences with standard error, P-value and percent heterogeneity.
*
indicates heterogeneity defined as I2>50% and P<0.05
Abbreviations: FFA=free fatty acid; IL-6=interleukin-6; TNFα=tumor necrosis factor alpha