Table 5.
Summary of Biomarkers Not Included in Meta-Analysis.
| Hormone/Inflammation | Number of studies | Antipsychotics (effect on biomarker) |
|---|---|---|
| ACTH | 2 | Haloperidol (↔), Olanzapine (↓), Quetiapine(↓*,↑) |
| CCK | 1 | Olanzapine (↑) |
| CRP | 2 | Olanzapine (↓,↔) |
| DHEA | 2 | Sulpride (↓*,↔) |
| E2 | 2 | Sulpride (↓,↓) |
| GIP | 1 | Olanzapine (↑) |
| GLP-1 | 2 | Olanzapine (↑,↔), Risperidone (↓) |
| Melatonin | 1 | Quetiapine (↔) |
| PP | 2 | Olanzapine (↑,↔) |
| Progesterone | 1 | Sulpride (↓) |
| PYY | 1 | Olanzapine (↔) |
| Testosterone | 2 | Sulpride (↔) |
| T4 | 2 | Sulpride (↑*,↔) |
↓* or ↑* indicates direction of effect of antipsychotic with a large effect size defined by a Hedges g greater than 0.8. ↓ or ↑ indicates direction of effect of antipsychotic with a medium effect size defined by a Hedges g of 0.2 to 0.79. ↔ indicates small to no effect with a Hedges g below 0.2.
Abbreviations: ACTH=Adrenocorticotropic hormone; CCK= Cholecystokinin; CRP=c-reactive protein; DHEA=Dehydroepiandrosterone; E2=estrogen; GIP=Gastric inhibitory polypeptide; GLP-1=Glucagon Like Peptide-1; PAI=Plasminogen activator inhibitor; PP=pancreatic polypeptide; PYY=peptide YY; T4=thyroxine