Table 2.

State of the art sequence-based PPI predictors.

Predictor	Type	Machine learning model	Features	Availability	Ref.
SPRINT	Similarity-based scoring	Not applicable	Not applicable	C++ source	15
PIPR	Machine learning	RCNN	Latent representation of protein sequences generated by a combination of convolution layers and re- sidual gated recurrent units	Python source	18
D-SCRIPT	Machine learning	Bi-LSTM + CNN	Combination of a pre-trained embedding model with a predicted contact map	Python package	24