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. 2022 Jun 10;12:9580. doi: 10.1038/s41598-022-13091-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Change in regional cerebral blood flow in left primary sensorimotor cortex. The region is defined using the probabilistic anatomical Juelich atlas. Areas BA4a, BA4b BA3a, BA3b and BA6 for the left hemisphere was used, and the mask was limited in each direction to fit the hand knob. Box and whisker plot of activation during TDCS at 0.5–2.0 mA (green shades) and finger-tapping before stimulation (FTpre) and after (FTpost) (orange shades). Y-axis shows activation in z-score. Outliers defined being beyond 1.5 inter-quartile range of each quartile.