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Priming and triggering signals regulating the assembly and activation of the NLRP3 inflammasome. Primining signals result in the transcription, primarily through NF-κB, of the NLRP3 inflammasome components. Triggering signals result in: NLRP3 inflammasome assembly; caspase-1 activation: cleavage of pro-IL-1β and pro-IL-18 into the mature forms; cleavage of GSDMD which forms pores on the cell membrane, allowing secretion of active IL-1β and IL-18.
