Table 1.

Summary of the clinico-pathological features of the reported cases of extra-osseous Ewing sarcoma, adamantinoma-like Ewing sarcoma and carcinomas of the thyroid with Ewing family tumor elements

	Age	Sex	FNA/ core needle biopsy	Tumor size	Adverse factor	Treatment	Follow up/outcome	p40/p63 expression	other
Adapa et al. [4]	9	F	Ewing sarcoma	6.0 cm	Lymph node metastasis	Chemotherapy, surgery, radiotherapy	6 years, ANED	N/A
Eloy et al. [11]	42	F	Follicular tumor	2.5 cm	Vascular invasion	Total thyroidectomy	38 months, ANED	Positive	CEFTE
Maldi et al. [6]	66	M	Malignant tumor of possible neuroectodermal origin	4.5 cm	Vascular invasion	Total thyroidectomy, no chemotherapy or radiotherapy	8 months/ AWED	Focal expression
Chirila et al. [7]	48	M	Giant B-cell non-Hodgkin lymphoma	10 cm	Positive surgical margins	CHOP (initial diagnosis of B cell non Hodgkin lymphoma), followed by etoposide and carboplatin	1 month, died from brain metastasis	N/A	No validation of EWSR1 fusion
Chan et al. [5]	23	M	Not performed	4.7 cm	Vascular invasion, lymph node metastasis	Total thyroidectomy, vincristine, actinomycin D, cyclophosphamide etoposide and radiotherapy	under chemotherapy	N/A
Chan et al. [5]	67	F	Bethesda IV	4.0 cm	Vascular invasion	Total thyroidectomy (2 steps), chemotherapy	22 months ANED	N/A
Eloy et al. [12]	24	M	Not performed	5.3 cm	Vascular invasion	Total thyroidectomy (2 steps), radioactive iodine	13 years/ ANED	Positive	CEFTE
Bishop et al. [8]	19	M	N/A	N/A	N/A	Surgery, additional therapy pending	0 month	Focally positive (< 5%)
Bishop et al. [8]	36	F	N/A	N/A	N/A	Surgery, additional therapy pending	0 month	Positive
Kabata et al. [15]	34	M	Small-cell malignant neoplasm, most likely of hematologic origin/ core needle bx: ewing sacoma	6.0 cm	Not reported	Neo-adj. chemotherapy isthmolobectomy, cervical lymphadenectomy, radiotherapy (discontinued)	18 months	N/A
Ongkeko et al. [20]	36	M	Suggestive of malignancy	7.0 cm	Extrathyroidal extension, lymphovascular invasion, lymph node metastases	Total thyroidectomy, medial and right lateral neck dissection, chemotherapy	2 years, ANED pancreatic metastasis treated by chemotherapy	N/A
Morlote et al. [21]	20	F	Suspicious for carcinoma	4.0 cm	Not reported	Total thyroidectomy, chemotherapy, radiotherapy	7 months ANED	Positive
Jones and Maleki [16]	21	M (transgender)	ALES	7.0 cm	N/A	N/A	N/A (numerous lytic bone lesions)	Positive
Chikeka et al. [17]	15	F	Bethesda VI	3.0 cm	Positive surgical margins	Total thyroidectomy, chemotherapy, radiotherapy	N/A	Positive
Taccogna et al. [10]	40	M	Bethesda V	6.5 cm	Not reported	Total thyroidectomy	6 months ANED	Positive	CEFTE
Current case	54	F	Bethesda VI PDTC	4.0 cm	Vascular invasion, positive surgical margins	Total thyroidectomy, chemotherapy, radiotherapy	15 months ANED	Negative

ANED alive, no evidence of disease, AWED alive with evidence of disease, N/A not available, CEFTE carcinoma of the thyroid with Ewing family tumor elements, ALES adamantinoma like Ewing sarcoma