Table 2.

Percentage of cases with CAFs_COL11A1 and clinicopathological features of the SGC cohort

	CAFsCOL11A1 score					p	n	Spearman coefficient
	0	1	2	3	4
Grade
G1	32.0%	16.0%	12.0%	24.0%	16.0%	0.754	72	− 0.37
G2	40.9%	0.0%	13.6%	36.4%	9.1%
G3	32.0%	16.0%	16.0%	28.0%	8.0%
pT
pT1	54.2%	12.5%	12.5%	16.7%	4.2%	0.209	104	0.125
pT2	40.7%	22.2%	7.4%	25.9%	3.7%
pT3	52.2%	0.0%	4.3%	21.7%	21.7%
pT4a	47.6%	4.8%	19.0%	23.8%	4.8%
pT4b	22.2%	22.2%	11.1%	33.3%	11.1%
N
pN0	52.3%	12.3%	9.2%	20.0%	6.2%	0.015	102	0.239
pN1	44.4%	22.2%	11.1%	22.2%	0.0%
pN2	28.6%	7.1%	14.3%	32.1%	17.9%
CD8
0	55.6%	11.1%	14.8%	18.5%	0.0%	0.017	109	0.228
1	48.1%	13.0%	7.4%	24.1%	7.4%
2	32.1%	7.1%	14.3%	28.6%	17.9%
Total	45.9 (50)	11.0 (12)	11.0 (12)	23.9 (26)	8.3 (9)

	Negative		Positive			p	n
pT
< pT3	46.2%		53.8%			1#	105
≥ pT3	45.3%		54.7%
pN
pN −	51.5%		48.5%			0.067#	103
pN +	32.4%		67.6%
V
V0	48.8%		51.2%			0.004*	91
V1	0.0%		100.0%
L
L0	46.9%		53.1%			0.334*	92
L1	27.3%		72.7%
Pn
Pn0	56.1%		43.9%			0.004#	96
Pn1	23.3%		76.7%
Age
< 65y	51.4%		48.6%			0.102#	110
≥ 65y	33.3%		66.7%
Sex
Women	45.9%		54.1%			1#	110
Men	44.9%		55.1%
TP53
Wildtype	51.4%		48.6%			0.088#	106
Mutated	31.3%		68.8%
CD8
Not inflamed	50.0%		50.0%			0.126#	110
Inflamed	32.1%		67.9%
Total	45.5 (50)		54.5 (60)

Upper half: CAFs_COL11A1 score in relation to ordinally scaled pathological attributes. Comparison of negative (CAFs_COL11A1 score = 0) and positive (CAFs_COL11A1 score > 0) cases with respect to nominally scaled clinicopathological parameters, given as percentage, absolute numbers in brackets. P values below 0.05 are indicated in bold type, p values below 0.1 are marked in italic

V vascular invasion, L lymphatic invasion, Pn perineural spread

#Chi-square test

*Fisher’s exact test (lower half)