Table 1.
Comparison of clinical and demographic findings of the literature review with the current series of oral juvenile xanthogranuloma
| Variable | Literature cases | References | Current cases | Total |
|---|---|---|---|---|
| Sex | ||||
| Male | 25 (67.6%) | [3–8, 16, 17, 20, 21, 23, 24, 26, 27, 29, 32, 34, 35, 37, 38] | 2 (40%) | 27 (64.3%) |
| Female | 12 (32.4%) | [6, 8, 18, 19, 22, 25, 28, 30, 31, 33, 36] | 3 (60%) | 15 (35.7%) |
| M:F ratio | 2.1:1 | 1:1.5 | 1.8:1 | |
| Age group (years) | ||||
| 0–9 | 20 (54.1%) | [3, 6, 8, 19, 20, 22, 26, 28, 30, 33–36, 38] | – | 20 (47.6%) |
| 10–19 | 9 (24.3%) | [6, 8, 18, 24, 31, 32, 37] | 1 (20%) | 10 (23.8%) |
| 20–29 | – | – | 1 (20%) | 1 (2.4%) |
| 30–39 | 4 (10.8%) | [16, 17, 21, 27] | 1 (20%) | 5 (11.9%) |
| 40–49 | 1 (2.7%) | [30] | – | 1 (2.4%) |
| 50–59 | 1 (2.7%) | [4] | 1 (20%) | 2 (4.8%) |
| 60–69 | 2 (5.4%) | [7, 29] | 1 (20%) | 3 (7.1%) |
| Median | 9 | 39 | 10.5 | |
| Range | 0–64 | 13–68 | 0–68 | |
| Anatomic location | ||||
| Gingiva | 11 (29.8%) | [4, 8, 18–22, 36, 37] | – | 11 (26.2%) |
| Tongue | 10 (27%) | [2, 8, 25–31] | 1 (20%) | 11 (26.2%) |
| Palate | 8 (21.6%) | [28, 33, 35–38] | – | 8 (19%) |
| Lip | 3 (8.1%) | [5, 6, 34] | 1 (20%) | 4 (9.5%) |
| Buccal mucosa | 3 (8.1%) | [8, 16, 17] | 3 (60%) | 6 (14.3%) |
| Alveolar ridge mucosa | 1 (2.7%) | [7] | – | 1 (2.4%) |
| Anterior mandibular vestibule | 1 (2.7%) | [32] | – | 1 (2.4%) |
| Symptomatology | ||||
| Asymptomatic | 22 (88%) | [3–8, 17, 19, 21–23, 25, 27, 29, 32, 34–36] | 3 (60%) | 25 (83.3%) |
| Pain | 3 (12%) | [26, 29, 31] | 2 (40%) | 5 (16.7%) |
| NI | 12 (32.43%) | [6, 18, 20, 24, 26, 28, 33, 37, 38] | – | 12 (28.57%) |
| Size (cm) | ||||
| Median | 1.4 | [3–6, 16, 17, 20, 21, 23–29, 31–38] | 1.5 | 1.5 |
| Range | 0.3–5 | 1.0–2.5 | 0.3–5.0 | |
| NI | 10 (27.0%) | [7, 8, 18, 19, 22, 30] | – | 11(26.19%) |
| Color | ||||
| Yellowish-brown | 14 (53.9%) | [3, 4, 6–8, 18–20, 24, 26, 32–34] | 1 (20%) | 15 (48.4%) |
| Reddish-pink | 6 (23.1%) | [5, 17, 22, 23, 30, 37] | 1 (20%) | 7 (22.6%) |
| Normal color | 4 (15.4%) | [17, 21, 29, 31] | 3 (60%) | 7 (22.6%) |
| Purple | 1 (3.8%) | [36] | – | 1 (3.2%) |
| White | 1 (3.8%) | [24] | – | 1 (3.2%) |
| NI | 11 (29.72%) | [8, 16, 24, 25, 27, 28, 38] | – | 11 (26.19%) |
| Skin lesions | ||||
| Yes | 3 (8.1%) | [20, 26, 36] | – | 3 (7.1%) |
| No | 34 (91.9%) | [3–8, 16–19, 21–25, 27–30, 32–35, 37, 38] | 5 (100%) | 39 (92.9%) |
| Visceral involvement | ||||
| No | 37 (100%) | [3–8, 16–38] | NI | 37 (100%) |
| Treatment | ||||
| Conservative surgical excision | 31 (96.9%) | [3–8, 16–19, 21–23, 25, 27–29, 31–38] | 5 (100%) | 36 (97.3%) |
| Spontaneous regression after incisional biopsy | 1 (3.1%) | [30] | – | 1 (2.7%) |
| NI | 5 (13.51%) | [20, 24, 26] | – | 5 (11.90%) |
| Recurrence | ||||
| Yes | 4 (13.8%) | [8, 19, 24, 35] | – | 4 (11.8%) |
| No | 25 (86.2%) | [3–6, 16–18, 21–23, 25, 28–32, 34, 36–38] | 5 (100%) | 30 (88.2%) |
| NI | 8 (21.62%) | [7, 20, 24, 26, 27, 33, 36] | – | 8 (19.04%) |
NI not informed