Table 2.
Clinicopathologic characteristics of patients with primary thyroid SC
| Year | Author | Age (years) | Sex | Size (cm) | Clinical presentation | Mitoses | Necrosis | Stage | Margins | Distant metastases | Local or regional recurrence | Outcome | Follow-up (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2016 | Reynolds | 36 | F | 4.5 | Bilateral thyroid mass with enlarged neck LNs and mediastinal extension | 1/30 HPF | Absent | T4aN1 | Positive | Yes, at recurrence (soft tissue, lung and liver) | Regional recurrence × 2 | DOD | 107 |
| 2016 | Dogan | 72 | F | 2.9 | Right thyroid mass with gross ETE and tracheal invasion | 1/10 HPF | Absent | T4aN0 | Focally positive | No | Regional recurrence × 2 | DOOC | 238 |
| 47 | M | 7.0 | Left thyroid mass with gross ETE and enlarged left neck LN | 1 per 10 HPF | Absent | T3N1b | Negative | No | Regional recurrence × 3 | NED | 230 | ||
| 65 | F | 6.5 | Isthmic thyroid mass with ETE and tracheal invasion | 1/10 HPF | Absent | T4aN0 | Positive | No | None | NED | 24 | ||
| 2017 | Dettloff | 52 | F | 2.4 | Left thyroid mass, No gross ETE | 3/10 HPF | Absent | T2N1a | NS | No | None | NED | 26 |
| 55 | F | 2.6 | Infiltrative thyroid mass involving perilaryngeal soft tissues | 2/10 HPF | Absent | T3N1b | NS | No | None | NED | 43 | ||
| 74 | M | 4.0 | Right thyroid mass, No gross ETE | 10/10 HPF | Present | T2N1b | NS | Yes, at recurrence (liver) | None | DOD | 12 | ||
| 2017 | Common case to Wu and Liao | 58 | F | 4.0 | Left thyroid mass with gross ETE, tracheal involvement and left recurrent laryngeal nerve impingement causing progressive hoarseness | 7/10 HPF | Present | T4aN0 | Positive | No | None | NED | 14 |
| 2018 | Asa | 72 | F | 2.5 | Left thyroid mass with gross ETE | NS | NS | T3N0 | NS | No | None | NED | 18 |
| 2019 | Desai | 74 | F | 7.6 | Thyromegaly with progressive dyspnea requiring intubation, ETE with tracheal compression | 2/10 HPF | Present | T4bN1b | Positive | Yes, at diagnosis (liver, lung, kidney, bone) | None (DOD) | DOD | 20 days |
| 2020 | Huang | 36 | F | 5.0 | Right thyroid mass with tumor thrombus in jugular vein | NS | NS | T3aN0 | Yes, 11 months later (lung) | None | AWD | 33 | |
| 2021 | Current case | 49 | M | 4.7 | Presented for hoarseness, found to have a left thyroid mass with left recurrent nerve and tracheal involvement | 3/10 HPF | Present | T4Nx | Focally positive | Yes, at recurrence (lung) | Regional recurrence × 3 | DOD | 181 |
NS Not specified, AWD Alive with disease, DOD Died of disease, DOOC Died of other causes, NED No evidence of disease, ETE Extrathyroidal extension, LN Lymph node