. 2022 Jun 11;47(10):2909–2924. doi: 10.1007/s11064-022-03646-5

Table 1.

Roles of MT1/2 receptors in theories of depression pathogenesis

Type of theories of depression pathogenesis	Type of melatonergic receptors
Type of theories of depression pathogenesis	MT1	MT2
Monoaminergic theories	Knockout leads to decrease in dorsal raphe nucleus 5-HT and locus coeruleus NE neuronal bursts activity [122]	Capacity to assemble into functional heteromers with 5-HT2C receptors [122, 123]
Monoaminergic theories	Agonists increase monoamine oxidase A levels [124]
Neuronal/synaptic remodeling theories	Activation may induce the expression of GDNF [121]	Activation enhances neurogenesis [110]
Immune and inflammation theories	Reduces neuroinflammation and releases IL-1β, IL-6, TNF-α [108, 125–127]