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. 2022 May 15;15(5):206–214.

Figure 3.

Figure 3

Luteolin inhibited the activation of Hippo/YAP signaling pathway and cell proliferation in HCC cells. A. The protein levels of MEF2D, AMOTL2, phosphorylated, and total YAPs were detected in HCC cells under the exposure with different doses of luteolin. B. The relative ratios of phosphorylated and total YAPs protein were determined in the above HCC cells. The data represent the means ± SDs of triplicate experiments. **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. C, D. Huh7 and PLC/PRF/5 cells were treated with luteolin at the specified concentration (0-80 μM) for 24 hours. The cell viability was detected by CCK8 test. This experimental result was obtained through more than three independent experiments. The data represent the means ± SDs of triplicate experiments. **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.