Table 2. Clinical Characteristics of the Cohorts at Baseline, From 2011 to 2018 .
| Cohort | No. of patients | Opioid exposure, No. (%) | Chronic pain, No. (%) | Substance use disorder, No. (%) | Anxiety disorder, No. (%) | Mood disorder, No. (%) |
|---|---|---|---|---|---|---|
| 1 | 5 755 311 | 1 325 452 (23.0) | 952 680 (16.6) | 77 817 (1.4) | 362 488 (6.3) | 477 471 (8.3) |
| 2 | 5 941 176 | 1 354 674 (22.8) | 1 026 348 (17.3) | 86 647 (1.5) | 410 550 (6.9) | 512 039 (8.6) |
| 3 | 5 408 548 | 1 201 900 (22.2) | 939 428 (17.4) | 85 993 (1.6) | 394 035 (7.3) | 480 302 (8.9) |
| 4 | 5 648 410 | 1 196 785 (21.2) | 988 546 (17.5) | 97 795 (1.7) | 431 554 (7.6) | 513 355 (9.1) |
| 5 | 6 150 982 | 1 257 374 (20.4) | 1 134 682 (18.4) | 118 160 (1.9) | 528 752 (8.6) | 588 679 (9.6) |
| 6 | 6 893 796 | 1 416 025 (20.5) | 1 345 654 (19.5) | 145 568 (2.1) | 690 767 (10.0) | 696 058 (10.1) |
| 7 | 7 610 075 | 1 470 354 (19.3) | 1 564 972 (20.6) | 170 512 (2.2) | 818 596 (10.8) | 813 041 (10.7) |