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. 2022 Jun 11;20:266. doi: 10.1186/s12967-022-03470-z

Table 3.

Adjusted hazard ratios and 95% confidence intervals for diabetes risk associated with the lipid parameters in different test populations: sensitivity analysis

HR (95% CI)
Sensitivity-1 Sensitivity-2 Sensitivity-3
HDL-C 0.63 (0.41, 0.99) 0.49 (0.29, 0.82) 0.50 (0.34, 0.75)
TC 0.99 (0.86, 1.14) 0.89 (0.73, 1.08) 0.97 (0.85, 1.10)
TG 1.17 (1.01, 1.34) 1.24 (1.00, 1.52) 1.30 (1.15, 1.46)
LDL-C 1.00 (0.85, 1.19) 0.94 (0.75, 1.18) 0.98 (0.84, 1.14)
Non-HDL-C 1.04 (0.90, 1.20) 0.99 (0.81, 1.20) 1.04 (0.92, 1.19)
RC 1.64 (0.98, 2.74) 1.74 (0.82, 3.72) 2.25 (1.44, 3.53)
TC/HDL-C ratio 1.10 (1.00, 1.21) 1.17 (1.01, 1.35) 1.15 (1.05, 1.26)
TG/HDL-C ratio 1.14 (1.02, 1.27) 1.19 (1.03, 1.37) 1.23 (1.13, 1.34)
Non-HDL/HDL-C ratio 1.10 (1.00, 1.21) 1.17 (1.01, 1.35) 1.15 (1.05, 1.26)
LDL/HDL-C ratio 1.11 (0.98, 1.26) 1.20 (1.00, 1.44) 1.16 (1.03, 1.29)
RC/HDL-C ratio 3.69 (1.09, 12.47) 14.01 (2.75, 71.47) 7.73 (2.68, 22.28)

Note 1: (1) sensitivity-1: subjects with a follow-up of less than 3 years were excluded (n = 11,237); (2) sensitivity-2: subjects diagnosed with fatty liver at baseline were excluded. (n = 12,823); (3) sensitivity-3: excluding subjects whose SBP ≥ 140 mmHg or DBP ≥ 90 mmHg (n = 14,878);

Note 2: sensitivity-1 adjusted for sex, age, BMI, habits of exercise, drinking status, smoking status, fatty liver, SBP, FPG, HbA1c, height, ALT, AST and GGT. Sensitivity-2 adjusted for sex, age, BMI, habits of exercise, drinking status, smoking status, SBP, FPG, HbA1c, height, ALT, AST and GGT. Sensitivity-3 adjusted for sex, age, BMI, habits of exercise, drinking status, smoking status, fatty liver, FPG, HbA1c, height, ALT, AST and GGT

HR hazard ratios; CI confidence interval; other abbreviations as in Table 1