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. 2022 Jun 11;27:45. doi: 10.1186/s11658-022-00351-7

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Fig. 1 — α-SMA-positive CAFs correlate with poor prognosis and more aggressive phenotype of tumor cells in lumBC. A Representative staining of α-SMA in TME of breast cancer samples, magnification 20×. B Overall survival (OS) in patients with luminal BC according to α-SMA protein level in CAFs. Hazard ratios (HR) with 95% confidence intervals (95% CI) were computed using Cox proportional hazards regression. C EpCAM and SNAIL expression in patients with low versus high α-SMA. Mann–Whitney U test was applied