Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 11;19:141. doi: 10.1186/s12974-022-02501-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 7 — ITBS inhibited expression of ASC in the peri-infarcted area. A Schematic representation of the distribution of necrotic cells, apoptotic/pyroptotic cells and activated glial cells in the different regions of the ischemic hemisphere, including ischemic core and peri-infarcted area. B Immunofluorescence staining for MAP2/ASC colocalization (MAP2-red and ASC-green) showed the location of pyroptotic cells among Sham, MCAO/r and iTBS groups. Scale bar = 40 μm. C Quantitative analysis of MAP2 fluorescence intensity showed that iTBS enhanced the expression of MAP2 in the peri-infarcted area. D ITBS significantly reduced the number of ASC positive cells in peri-infarcted area rather than at the border of infarcted core. E MAP2/ASC colocalization analysis revealed that iTBS significantly reduced the expression of ASC on neurons in the peri-infarcted area compared with MCAO/r group. Values are expressed as the mean and 95% confidence interval (n = 4). Non-significant (ns), *P < 0.05, **P < 0.01 as determined by one-way ANOVA (Tukey’s multiple comparison test) and two-way ANOVA (Bonferroni's multiple comparison test)