Table 2.

Comparisons of single and combined circulating miRNAs as predictors of critical COVID-19 patients

Groups	miRNA	AUC (95% CI)	Sensitivity (%)	Specificity (%)	p value
Critical COVID-19 versus COVID-19-negative control	hsa-miR-98-3p	0.8264 (0.6538–0.9991)	72.73	63.64	0.0095
	hsa-miR-423-3p	0.7875 (0.6199–0.9551)	75.00	73.33	0.0064
	hsa-miR-1246	0.8750 (0.755–0.995)	82.35	87.50	0.0002
	hsa-miR-98-3p + hsa-miR-423-3p + hsa-miR-1246	0.6634 (0.5484–0.7784)	63.64	69.05	0.0091
Critical COVID-19 versus asymptomatic IgG-positive COVID-19	hsa-miR-32-5p	0.7490 (0.5799–0.9181)	76.47	60.00	0.0165
	hsa-miR-1246	0.8824 (0.7681–0.9966)	82.35	87.50	0.0002
	hsa-miR-32-5p + hsa-miR-1246	0.7913 (0.6831–0.8994)	73.53	64.52	<0.0001