Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 11;41:200. doi: 10.1186/s13046-022-02390-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — STAT3/FOXM1/ATG7 signalling is essential for icotinib resistance. A Immunoblotting was performed to determine the impact of FOXM1 blockade on protein expression of ATG7. B-D Representative results of protein changes of FOXM1 and ATG7 levels (B), autophagic flux with the mRFP-GFP-LC3 reporter (C), and cell apoptosis (D) in icotinib-treated cells in response to FOXM1 knockdown with two specific siRNAs against FOXM1. E Expression of ATG7 was detected in icotinib-treated cells transfected with STAT3-CA and siFOXM1 alone or combination. [***P < 0.001, ns, no significance as compared with the DMSO group. ###P < 0.001 as compared with the icotinib group. ζζζP < 0.001 as compared with icotinib plus STAT3WT and siNC. ξξξP < 0.001 as compared with icotinib plus STAT3-Y705F and siNC]