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. 2022 Jun 11;41:200. doi: 10.1186/s13046-022-02390-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Chloroquine and STAT3/FOXM1 signalling blockade effectively sensitize EGFR-mutated NSCLC cells to icotinib in vivo. A Tumours were excised and collected after treatment with icotinib/CQ alone or the combination for 21 days. B-D Tumour weight (B), tumour volume (C), and body weight (D) of indicated xenografts are shown. E Immunoblotting assays measured LC3 conversion and the expression of STAT3, FOXM1, and ATG7. F Paraffin-embedded sections of tumour tissues from xenografted mice were analyzed by TUNEL staining. Scale bar: 10 μm. G Ultrastructural changes of autophagic vesicles and apoptotic bodies in tumour tissues of indicated xenografts are shown. Scale bar: 1 μm. P, phagosome. AP, autophagosome. AL, autolysosome. AC, apoptotic cell. AB, apoptotic body. ER, endoplasmic reticulum. M, mitochondrion. Golgi, golgi apparatus. H Xenograft tumours were excised from the group of icotinib, LV-STAT3-Y705F and shFOXM1 alone or combination. I-K) Tumour weight (I), tumour volume (J), and growth curve (K) of indicated xenografts are shown. [**P < 0.01, ***P < 0.001, ns, no significance as compared with the control group. #P < 0.05, ###P < 0.001 as compared with the icotinib alone group. ζP < 0.05, ζζζP < 0.001 as compared with icotinib plus LV-STAT3WT, ξP < 0.05, ξξP < 0.01 as compared with icotinib plus shNC. ††P < 0.01, †††P < 0.001 as compared with icotinib plus LV-STAT3-Y705F. φφP < 0.01, φφφP < 0.001 as compared with icotinib plus shFOXM1]