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. 2022 Jun 11;41:200. doi: 10.1186/s13046-022-02390-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Clinical significance of STAT3/FOXM1/ATG7 signalling in response of EGFR-mutated NSCLC patients to EGFR-TKIs. A The proportion of high and low p-STAT3 (Y705), FOXM1, and ATG7 expression in EGFR-TKIs-sensitive (n = 32) and EGFR-TKIs-resistant (n = 31) patients. B Representative images of immunohistochemical staining for phosphorylated STAT3(Y705), FOXM1 and ATG7 in the tumour tissues from EGFR-TKIs-sensitive and EGFR-TKIs-resistant patients. Statistical analysis of IRS of the indicated proteins in each group is depicted. Scale bars, 20 μm. C The correlation of active STAT3, FOXM1, and ATG7 in EGFR-TKIs-resistant patients harbouring EGFR mutation. D Kaplan–Meier analysis of PFS in resistant patients after EGFR-TKIs treatment (n = 31) further stratified with low and high expression of phosphorylated STAT3(Y705), FOXM1 and ATG7 levels. [*P < 0.01, **P < 0.01, ***P < 0.001 as compared with the pre-EGFR-TKIs group]