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. 2022 Jun 10;19:49. doi: 10.1186/s12987-022-00345-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — OVX on ⁵⁵Fe-Tf brain uptake in females. Samples are reported as DPM per gram of brain tissue. After removing circulating estrogen via OVX, female mice still do not show changes in ⁵⁵Fe-Tf uptake (A), release (B), or total uptake (C) across infusion conditions. Intact sham mice were included as a control. The coefficient of variability of ⁵⁵Fe-Tf uptake in sham conditions was 16.15%. The levels of plasma estradiol levels were determined to confirm the success of the OVX in all mice used (D). The TIBC of plasma is higher in OVX mice while the Tf saturation percentage and serum iron are lower when compared to control (E). n= 5 for all conditions, means of biological replicates ± SD were evaluated for statistical significance using one-way ANOVA with Tukey’s posttest for significance for A and B. Means ± SD were evaluated for statistical significance using unpaired t-test for significance for C and D. **** p<0.0001