Figure 6.

Mutations of interest selected using model importance coupled SHAP value assessment for Low vs High severity prediction across important geographies of the world. Bee-swarm plot indicates the contribution of presence/absence of a mutation towards High or Low severity outcome of XgBoost based classification model. Values greater than zero indicate contribution towards a severe outcome, while SHAP values less than zero indicate contribution to less severe outcome of the model. Additionally, the labels of the mutations have been colored according to the protein in which the said mutations appear.