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. 2022 May 27;42(6):513–524. doi: 10.1007/s40261-022-01156-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 4 — Geometric mean ratio and 90% confidence interval showing the effect of food and evening fasting on exposure to trofinetide: whole blood pharmacokinetic analysis set. AUC_0–t area under the blood concentration-time curve from time 0 to time t, AUC_0–∞ area under the blood concentration-time curve from time 0 to infinity, CI confidence interval, C_max maximum observed drug concentration, GMR geometric mean ratio