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. 2022 Jun 11;8:285. doi: 10.1038/s41420-022-01066-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Western blot showed that PPARγ expression was decreased after GW9662 treatment in HN31 cells. B, C Clustered heatmap of a significant differentially expressed gene in UM1 and HN31 cells treated by GW9662. Each sample contained a mixture of three repeats. D Venn diagram showed MMP13, STRA6, and PTPRH were downregulated after GW9662 treatment in both HN31 and UM1 cells. E Western blot analysis showed inhibition of PPARγ could decrease the expression level of p65, p-P65, Rel B, and MMP13. F Rescue analysis indicated that miR-27a and miR-27b inhibitors could alleviate the reduction of PPARγ, p65, p-P65, Rel B, and MMP13 by inhibiting the expression of circRFWD3. Data were shown as representative of one experiment with three independent biological replicates.