Figure 1.

Literature tree of the 526 studies returned from the PubMed search concerning epigenetic endpoints for the human carcinogens included in IARC Monograph 100F (all classified as “Group 1”). The studies were categorized based on inclusion or exclusion criteria as shown. Included studies were further sorted, in order, by cancer hazard, species studied (human, rat, mouse, or other), study design (in vivo or in vitro), and epigenetic endpoint. The numbers within each circle denote how many studies were allocated to that specific category. Blue circles denote that they contain additional sub-categories. White circles indicate a terminal category. The literature tree branches for included studies for carcinogens “Benzene” and “Formaldehyde” are expanded for illustration purposes. The branch for “No Epigenetics” category is shown as an example of an exclusion category. The searches covered literature published between 12/2015 and 12/2020.