Table 2.

A total number of publications (until December 2020) with data related to epigenetic alterations for each Group 1 carcinogen included in the systematic literature review.

Group 1 carcinogen	Most Recent Monogr. Listed		DNA Methylation			Histone Modifications			Non-Coding RNAs
			Humans	Rodents (mouse or rat)	Other (See footnotes)	Humans	Rodents (mouse or rat)	Other (See footnotes)	Humans	Rodents (mouse or rat)	Other (See footnotes)	Total
1,3-Butadiene	100F	in vitro										0
		in vivo		5			5			1		11
4-Aminobiphenyl	100F	in vitro				1			2			3
		in vivo										0
Aflatoxins (naturally occurring mixtures)	100F	in vitro	8		1n, 2o	1		1o	8	1		22
		in vivo	11	4	1r		1	1r	4	8	1c, 1p	32
Benzene	100F	in vitro	11	2		3	1		10	1		28
		in vivo	23	2		5	1		12	2		45
Benzidine	100F	in vitro										0
		in vivo		1								1
Benzo[a]pyrene	100F	in vitro	18	6	3n, 2i	15	2	1h	26	4		77
		in vivo	11	12	6w, 2m, 1g, 1r,1s		3		2	13	1g, 1j, 1t, 1k, 1f	57
Coal-tar pitch	100F	in vitro	1						2			3
		in vivo										0
Coke production, occupational exposure	100F	in vitro	1									1
		in vivo	10			3			4			14
1,2-Dichloropropane	110	in vitro										0
		in vivo										0
Engine exhaust, diesel	105	in vitro	2			2			5			9
		in vivo	6	5					3			14
Formaldehyde	100F	in vitro	1			3		1v	1			7
		in vivo	1							3	1d	5
Lindane	113	in vitro										0
		in vivo		1								1
4-4′-Methylenebis (2-chlorobenzenamine)	100F	in vitro					1					1
		in vivo										0
Occupational exposure as a painter	100F	in vitro										0
		in vivo	1						1			2
Outdoor air pollution	109	in vitro	7			3			16			26
		in vivo	83	12	1b, 1e	4	3		26	12	1w	143
Pentachlorophenol	117	in vitro										0
		in vivo								1		1
Polychlorinated biphenyls (non-dioxin-like)	107	in vitro	3	1	1u	1	1		2	1	2c	12
		in vivo	19	11	1l, 1q, 1a, 1m		1		2	3	2w	42
Polychlorinated biphenyls (dioxin-like)	107	in vitro	1			2	1		1			6
		in vivo	3	3	1w				2			8
Sulfur mustard	100F	in vitro	2			1			2			5
		in vivo							6	2		8
Trichloroethylene	106	in vitro	8	2		4			2	2	2e	20
		in vivo	1	18			2		1	4	1w	27
Vinyl chloride	100F	in vitro										0
		in vivo	3	1					1			5
Welding fumes	118	in vitro	1	1								2
		in vivo	3	2					1			6

^aAlaska blackfish (Dallia pectoralis)

^bBarn swallow (Hirundo rustica)

^cChicken (Gallus gallus domesticus)

^dCynomulgus macaques (Macaca fascicularis)

^eDog (Canis lupis familiaris)

^fFirefly (Coleoptera lampyridea)

^gFish (Oeyzias melastigma)

^hFrog (Xenopus borealis)

ⁱHamster (Mesocricetus auratus)

^jJapanese Rice Fish (Oryzias latipes)

^kLancelet (Brachiostoma belcheri)

^lLoggerhead sea turtle (Caretta caretta)

^mMumichog fish (Fundulus heteroclitus)

ⁿOligodeozynucleotides

^oPig (Sus domesticus)

^pPig (Sus scrofa domesticus)

^qPond Slider (Trachemys scripta)

^rRainbow trout (Oncorhynchus mykiss)

^sRock dove (Columba livia)

^tRoundworm (Caenorhabditis elegans)

^uSheep (Ovis aries)

^vSynthetic peptide

^wZebrafish (Danio rerio)