Figure 1.

Approaches to drug discovery in pulmonary regenerative medicine. In vitro, in vivo, exvivo, and in silico modeling of respiratory lung diseases may be used for target identification as well as serve as the model to test drug efficacy. Thus, these complementary approaches contribute to development of new drug candidates, and these can be used in (semi) high-throughput screening approaches (depending on the technique). Such screening approaches are also particularly worthwhile for drug repurposing. Candidate drugs selected using such screens can be further analyzed and validated using the abovementioned in vivo, in vitro, and in silico approaches and lead to regenerative pulmonary medicine for a variety of lung diseases.