Table 1.
Overview of the various stem/progenitor populations in the mouse and human lung.
| Cell type | Marker expression | Differentiation/cell fate | Location/species | References |
|---|---|---|---|---|
| Basal cell | TP63, KRT5, NGFR | Self; airway luminal cells (including secretory goblet and club cells, and ciliated cells) | Airway Human/mouse |
[11,12,14,49] |
| Club/secretory cell | Scgb1a1 | Self; ciliated cells | Airway Human/mouse |
[15,16] |
| Myoepithelial cell | TP63, Scgb1a1 | Self; basal and luminal cells | Submucosal gland Mouse |
[50] |
| Distal airway cell populations (BASC, DASC, LNEP, MHChigh [H2-K1high]) | Various markers (depending on the subpopulation) | Self; basal, club, ciliated cells; AT1, AT2 | Distal airways Mouse |
Reviewed in [5] |
| AT2 | SFTPC, HT2-280, DC-LAMP, ABCA-3 | Self; AT1 | Alveoli Human/mouse |
[17] |
| AEP | SFTPC, HT2-280, Axin2/TM4SF1 | Self; AT2; AT1 | Alveoli Human/mouse |
[18,51] |
ABCA-3: ATP-binding cassette sub-family A member 3; AEP: alveolar epithelial progenitor cell; BASC: bronchioalveolar stem cell; DASC: distal airway stem cell; DC-LAMP: dendritic cell lysosomal-associated membrane glycoprotein; H2-K1: mouse MHC class I marker; KRT5: keratin 5; LNEP: lineage-negative epithelial progenitor; NGFR: nerve growth factor receptor; Scgb1a1: secretoglobin family 1A member 1; SFTPC: surfactant protein C; TM4SF1: transmembrane 4 L six family member 1; TP63: tumor protein p63.