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. Author manuscript; available in PMC: 2022 Jun 12.
Published in final edited form as: Nat Rev Endocrinol. 2020 Jun 25;16(9):506–518. doi: 10.1038/s41574-020-0375-3

Fig. 3 |. Stem cell bioprocessing for pancreatic islet cell manufacturing.

Fig. 3 |

Multiplate systems, roller bottles, bag bioreactors featuring a rocking motion and stirred suspension bioreactors are candidate cultivation modalities for the generation of clinically relevant quantities of islet cells from hPSCs. Stirred suspension bioreactors afford flexibility as cells can be grown and differentiated as aggregates, on microcarriers or following encapsulation. Moreover, these systems allow monitoring and control of the culture environment.