Table 1.
Characteristics of CYP3A5 non-expressor and expressor
| Variable | CYP3A5 non-expressora) | CYP3A5 expressorb) |
|---|---|---|
| Mean age (yr) | 39.9±12.1 | 38.2±10.9 |
| Sex | ||
| Male | 20 | 16 |
| Female | 13 | 5 |
| Weight (kg) | 57.79±11.2 | 57.90±10.0 |
| Transplant | ||
| First | 33 | 21 |
| Second | 0 | 0 |
| Type of donor | ||
| Living related | 29 | 18 |
| Living unrelated | 4 | 3 |
| Cause of chronic kidney disease | ||
| Glomerulonephritis | 2 | 2 |
| Chronic pyelonephritis | 4 | 2 |
| Diabetic nephropathy | 4 | 3 |
| Hypertensive nephropathy | 18 | 11 |
| Undetermined | 3 | 2 |
| Others | 2 | 1 |
| Immunosuppressant use | ||
| Prednisone | 33 | 21 |
| Mycophenolate mofetil | 33 | 21 |
| Tacrolimus | 33 | 21 |
| Trough concentration (ng/mL) | 7.14±2.56 | 5.92±1.76 |
| Concentration dose ratio (ng/mL/mg) | 6.92±4.11 | 2.89±1.85 |
| Apparent clearance (L/hr) | 12.53±5.28 | 21.22±5.95 |
Values are presented as mean¡¾standard deviation.
a)
CYP3A5*3/*3, n=33; b)CYP3A5*3/*1 and CYP3A%*1/*1, n=21.