Table 3.
COPD-Related Outcomes in Offspring
| Study | Predictive Models of Association Between Family History of COPD and Outcomes |
|---|---|
| Moll20 | ECLIPSE data SGRQ: OR=3.6 (95% CI 1.4–5.8) (P = 0.0008) No association: Frequent exacerbations, 6MWD and BODE Emphysema: NA |
| Moll20 | COPDGene data Non-Hispanic whites: Frequent exacerbations: OR= 1.65 (95% CI 1.26 to 2.16) 6MWD: −27m (95% CI −49 to −5.4) (P = 0.016) SGRQ: OR= 0.27 (95% CI 0.21–0.33) (P < 0.001) Paraseptal emphysema: OR= 1.57 (95% CI 1.17 −2.11) (P =0.0029) BODE: OR=0.43 (95% CI 0.3–0.56) (P < 0.001) African-Americans: SGRQ: OR=0.39 (95% CI 0.26 to 0.52) (P < 0.001) BODE: OR=0.61 (95% CI 0.39 to 0.83) (P < 0.001) Paraseptal emphysema: OR=1.68 (95% CI 1.04 to 2.7) (P = 0.034) No association: Frequent exacerbations and 6MWD |
| Study | COPD-related outcomes in COPD offspring with parental COPD exposure vs no parental COPD exposure |
| Hersh26 | FEV1 (%-predicted): 47.7±18.4 vs 50.5±18.3 (P = 0.0004) Dyspnea (mMRC): 2.4±21.3 vs 2.0±1.5 (P = 0.0001) BODE: 3.4±2.1 vs 2.9±2.1 (P = 0.0003) Number of severe exacerbations in the past year: 95 (26.9%) vs 88 (18.8%) (P = 0.0057) SGRQ score: 43.4±20.5 vs 36.2±21.2 (P < 0.0001) No association: 6MWD, emphysema |
Notes: No association: P-value > 0.05.
Abbreviations: BODE index, body mass index, obstruction, dyspnoea and exercise capacity; SGRQ, total St. George’s Respiratory Questionnaire score; mMRC, modified Medical Research Council; FEV1, forced expiratory volume in 1 second; m, meters; 6MWD, 6-minute walking test; NA, not available; COPD, chronic obstructive pulmonary disease.