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. 2022 Jun 13;40(1):111022. doi: 10.1016/j.celrep.2022.111022

Figure 4.

Figure 4

Temporal evolution of antibody specificity at the FP and SH epitopes in vaccinated and convalescent subjects

(A) Log-transformed ratio of PepSeq Z scores for the SARS-CoV-2 and endemic HCoV homologs (“specificity index”) of IgG reactivity against the FP and SH epitopes, plotted against days post-vaccination. Shown are data points in which reactivity against the focal epitope exceeds the threshold of detection (Z score ≥ 10) (in either the SARS-CoV-2 or the HCoV homologs), and lines connect data points from the same subjects.

(B) Specificity index of the antibody responses at the FP and SH epitopes in unvaccinated COVID-19 convalescent subjects dichotomized by days post-infection and analyzed using the ratio described in (A). Each point represents the mean of two technical replicates. Number of samples included in each boxplot range from 10 to 16 as indicated; t test: ∗p < 0.05, ∗∗∗p < 0.001.